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SUPPRESS - How Does It Work?

Posted on July 27 2018

SUPPRESS is a natural appetite suppressant (NOT a fat burner) dosed at precise levels to support your weight loss goals. The effective ingredients work together to boost your mood, reduce hunger, and help you feel fuller from fewer calories.

We're hugely excited about this. When formulating SUPPRESS, we wanted to hit a few key targets that would create a product that was effective, yet totally unique: 

  • NO stimulants whatsoever. We wanted a product that would still be effective in the evening, when most people are prone to over-eating. 
  • NO proprietary blends, only HUMAN research-backed doses. We're sick of seeing products that could be effective, but the label says "Proprietary Blend" - if that's the case, you have no idea whether you're getting the right dose for you. Everything in SUPPRESS has been shown to be effective in humans in multiple high-quality studies. No animal research here!
  • EFFECTIVE via multiple pathways. Appetite and food intake depends on a few physiological pathways, so we created a product using proven ingredients which work on multiple appetite control pathways to give you more than any single ingredient could on its own.
  • Improves overall HEALTH. A lot of people want to lose weight in order to improve their health - wouldn't it be great if we could offer something that could aid in weight loss, but also improve blood sugar regulation, waist:hip ratio and even cholesterol levels?

Suppress-Work

 

Suppress Increases Fullness/Satiety

All the ingredients in SUPPRESS have been shown to contribute to increased fullness or satiety - a key part of successful weight management. 

In a 1999 study, men given 18mg of capsaicin (the major active ingredient in Capsimax®) in an appetiser ate 200 kcal less at lunch and an afternoon snack compared to those who ate an appetiser containing no capsaicin. [1] A 2011 meta-analysis on capsaicin highlighted 6 studies that showed a clear suppressive effect on appetite in humans, and concluded "the balance of the literature suggests that capsaicin and capsiate suppress orexigenic sensations... Purposeful inclusion of these compounds in the diet may aid weight management". [2]

Glucomannan is a dietary fiber derived from konjac root. It's unique because, when exposed to water, it can swell up to 17 times its original volume - anyone who's eaten high-volume foods before knows how filling they can be. Most of the studies showing an effect on weight loss use a dose of 1000 mg taken before meals - 3000 mg of glucomannan a day for 8 weeks enabled 20 overweight women to lose 5.5 lbs without changing their diet or exercise habits. [3] The evidence-base for glucomannan for weight loss is small, but promising.

4 studies on 5-HTP demonstrated successful weight loss of 3-5 lbs over the course of 2-6 weeks without intentionally dieting, using doses of 750-900 mg of 5-HTP. [4-7]

 Ingredient
Research Dose for Appetite Suppression
SUPPRESS Daily Dose (assuming 3 servings per day)
Capsaicin
1-1000 mg
102 mg Capsimax®
Glucomannan
3000-5000 mg per day, usually 1000 mg before meals
3000 mg
5-HTP
750-900 mg per day
750 mg

 

Suppress Improves Mood

Anyone who's cut weight for powerlifting, prepped for a bodybuilding show or even dieted for an extended period of time knows that being hangry is real. 5-HTP is a direct precursor to serotonin, which is a neurotransmitter known to improve mood. [8] In fact, some studies have shown that 5-HTP is comparable to antidepressants to combat depression and anxiety. [9-11]

 

 Ingredient Research Dose for Mood Improvement SUPPRESS Daily Dose (assuming 3 servings per day)
5-HTP 300-900 mg per day 750 mg

Suppress Decreases Carbohydrate Cravings

Towards the tail end of a bodybuilding prep, or for a short-term weight cut, there's going to come a point where your carbohydrate intake needs to drop. At this point, cravings can really kick in - but SUPPRESS is here to help. In one study, 750 mg of 5-HTP per day reduced subjects' carbohydrate intake by 75% over a 2-week period without any prescribed dietary restriction. [7] Another study showed that a capsaicin-spiked appetiser reduced carbohydrate intake during an unrestricted buffet lunch and afternoon snack. [1]

 

 Ingredient Research Dose for Reducing Carbohydrate Intake SUPPRESS Daily Dose (assuming 3 servings per day)
Capsaicin 18 mg before each meal 102 mg Capsimax®
5-HTP 750 mg per day 750 mg

Suppress Improves Blood Glucose Regulation 

Impaired blood glucose control is linked with a whole host of issues when it comes to losing or maintaining weight. Glucomannan has been linked in a number of studies with improved blood glucose control. [12-15]

 

 Ingredient Research Dose for Improving Blood Glucose Control SUPPRESS Daily Dose (assuming 3 servings per day)
Glucomannan 400-3000 mg per day 3000 mg 

Other Health Benefits of Suppress 

A number of studies, including meta-analyses, have shown that the doses of glucomannan and capsaicin in SUPPRESS can [16-22]: 

  • Improve blood pressure 
  • Improve cholesterol levels and ratio of LDL:HDL
  • Improve waist:hip ratio

 

 As you can see - SUPPRESS offers research-backed doses of effective ingredients. We all know that the best fat burner is a calorie deficit - all SUPPRESS does is offer a helping hand for when the dieting gets tough.

 Ingredient
Research Dose
SUPPRESS Daily Dose (assuming 3 servings per day)
Capsaicin
1-1000 mg
102 mg Capsimax®
Glucomannan
3000-5000 mg per day, usually 1000 mg before meals
3000 mg
5-HTP
750-900 mg per day
750 mg

 

The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References

1. Yoshioka et al. Effects of red pepper on appetite and energy intake British Journal of Nutrition (1999), 82: 115–123.

2. Ludy et al. The Effects of Capsaicin and Capsiate on Energy Balance: Critical Review and Meta-analyses of Studies in Humans Chem. Senses (2012), 37: 103–121.

3. Walsh et al. Effect of glucomannan on obese patients: a clinical study. Int J Obes. (1984), 8: 289-293.

4. Cangiano et al. The effects of oral 5-hydroxytryptophan administration on feedingbehavior in obese adult female subjects. J Neural Transm. (1989) 76:109-117.

5. Cangiano et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr. (1992) 56: 863-867.

6. Cangiano et al. Effects of 5-Hydroxytryptophan on eating behavior and adherence to dietary prescriptions in obese adult subjects. Adv Exp Med Biol. (1991) 294: 591-593.

7. Cangiano et al. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int J Obes Relat Metab Disord. (1998) 22: 648-654.

8. Young and Leyton, The role of serotonin in human mood and social interaction: Insight from altered tryptophan levels, Pharmacology Biochemistry and Behavior (2002) Volume 71, 4: 857-865.

9. Byerley et al. 5-hydroxytryptophan: a review of its antidepressant efficacy and adverse effects. J Clin Psychopharmacol. (1987) 7:127-137.

10. Poldinger et al. A functional-dimensional approach to depression: Serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine, Psychopathology (1991) 24: 53-81.

11. Kahn et al. Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo, Int Clin Psychopharmacol. (1987) 2: 33-45.

12. Vuksan et al. Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial. Diabetes Care. (1999) 22:913-919.

13. Doi K. Effect of konjac fibre (glucomannan) on glucose and lipids. Eur J Clin Nutr. (1995) 3:190-197.

14. Chen et al. Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subjects-a randomized double-blind trial. J Am Coll Nutr. (2003) 22: 36-42.

15. Sood et al. Effect of glucomannan on plasma lipid and glucose concentrations, bodyweight, and blood pressure: systematic review and meta-analysis. Am J Clin Nutr. (2008) 88:1167-1175.

16. Arvill A, Bodin L. Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men. Am J Clin Nutr. (1995) 61:585-589.

17. Reffo GC, Ghirardi PE, Forattani C. Double-blind evaluation of glucomannan versus placebo in postinfarcted patients after cardiac rehabilitation. Curr Res Ther. (1990);47:753-758.

18. Venter CS, Kruger HS, Vorster HH, et al. The effects of dietary fiber component konjac-glucomannan on serum cholesterol levels of hypercholesterolemic subjects. Hum Nutr Food Sci Nutr. (1987) 41F:55-61.

19. Reffo GC. Glucomannan in hypertensive outpatients: pilot clinical trial. Curr Ther Res. (1988) 44:22-27.

20. Vuksan V, Jenkins DJ, Spadafora P, et al. Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial. Diabetes Care. (1999) 22:913-919.

21. Walsh DE, Yaghoubian V, Behforooz A. Effect of glucomannan on obese patients: a clinical study. Int J Obes. (1984) 8:289-293.

22. Urbina et al, Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals, Appetite (2017) 113: 264-273

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